Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies.

@article{Esposito2015LargescaleAO,
  title={Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies.},
  author={Laura Esposito and Jan Felix Drexler and Oliver Braganza and Elke Doberentz and Alexander Grote and Guido Widman and Christian Drosten and Anna Maria Eis-Huebinger and Susanne Schoch and Christian Erich Elger and Albert J. Becker and Pitt Niehusmann},
  journal={Epilepsia},
  year={2015},
  volume={56 2},
  pages={234-43}
}
OBJECTIVE Chronic inflammatory processes are important promotors of temporal lobe epilepsy (TLE) development. Based on human herpesvirus 6 (HHV-6) DNA detection in brain tissue from patients with TLE, an association of persistent viral infection with TLE has been discussed. Individual studies reported increased HHV-6 DNA in patients with clinical signs of previous inflammatory brain reaction, that is, febrile seizures or meningoencephalitis. However, detection rates vary considerably between… CONTINUE READING

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