Large-scale analysis of gene expression changes during acute and chronic exposure to [Delta]9-THC in rats.

@article{Kittler2000LargescaleAO,
  title={Large-scale analysis of gene expression changes during acute and chronic exposure to [Delta]9-THC in rats.},
  author={Josef T. Kittler and Elena V. Grigorenko and Chris L. Clayton and Si-yong Zhuang and Sarah C. Bundey and Michael M. Trower and Don M. Wallace and Robert E. Hampson and Sam A. Deadwyler},
  journal={Physiological genomics},
  year={2000},
  volume={3 3},
  pages={
          175-85
        }
}
Large-scale cDNA microarrays were employed to assess transient changes in gene expression levels following acute and chronic exposure to cannabinoids in rats. A total of 24,456 cDNA clones were randomly selected from a rat brain cDNA library, amplified by PCR, and arrayed at high density to investigate differential gene expression profiles following acute (24 h), intermediate (7 days), and chronic (21 days) exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the psychoactive ingredient of… 

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