Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.

  title={Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis.},
  author={Joyce B. J. van Meurs and Thomas A. Trikalinos and Stuart H. Ralston and Susana Balcells and Maria Luisa Brandi and Kim Brixen and Douglas P Kiel and Bente Lomholt Langdahl and P J A Lips and Osten Ljunggren and Roman S. Lorenc and Barbara Obermayer-Pietsch and C Ohlsson and Ulrika Pettersson and David M. Reid and François Rousseau and Serena A. Scollen and Wim van Hul and L{\'i}dia {\'A}gueda and Kristina E {\AA}kesson and Lidia I Benevolenskaya and Serge Ferrari and G{\"o}ran Hallmans and Albert Hofman and Lise Bjerre Husted and Marcin Kruk and Stephen K Kaptoge and David Karasik and Magnus K. Karlsson and Mattias Lorentzon and Laura Masi and F E McGuigan and D. D. Mellstr{\"o}m and Leif Mosekilde and Xavier Nogu{\'e}s and Huibert A. P. Pols and Jonathan Reeve and Wilfried Renner and Fernando Rivadeneira and Natasja M. van Schoor and Kurt Weber and John P. A. Ioannidis and Andr{\'e} G. Uitterlinden},
  volume={299 11},
CONTEXT Mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population. OBJECTIVE To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated with BMD and fracture risk. DESIGN AND SETTING Prospective, multicenter, collaborative study of… CONTINUE READING