Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity

@article{Ceron2007LargescaleRS,
  title={Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity},
  author={Julian Ceron and Jean-François Rual and Abha Chandra and Denis Dupuy and Marc Vidal and Sander van den Heuvel},
  journal={BMC Developmental Biology},
  year={2007},
  volume={7},
  pages={30 - 30}
}
The retinoblastoma tumor suppressor (Rb) acts in a conserved pathway that is deregulated in most human cancers. Inactivation of the single Rb-related gene in Caenorhabditis elegans, lin-35, has only limited effects on viability and fertility, yet causes changes in cell-fate and cell-cycle regulation when combined with inactivation of specific other genes. For instance, lin-35 Rb is a synthetic multivulva (synMuv) class B gene, which causes a multivulva phenotype when inactivated simultaneously… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

Distinct Caenorhabditis elegans HLH-8/twist-containing dimers function in the mesoderm.

Developmental dynamics : an official publication of the American Association of Anatomists • 2012
View 5 Excerpts
Highly Influenced

Neuropeptide GPCRs in C. elegans

Front. Endocrin. • 2012
View 9 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 72 references

Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…