Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosis

@article{Rovaris2008LargescaleMQ,
  title={Large-scale, multicentre, quantitative MRI study of brain and cord damage in primary progressive multiple sclerosis},
  author={Marco Rovaris and Elda Judica and Jaume Sastre-Garriga and Alex Rovira and Maria Pia Sormani and Beatrice Benedetti and T. Korteweg and Nicola de Stefano and Zhaleh Khaleeli and Xavier Montalban and Frederik Barkhof and David H. Miller and Chris Polman and Alan J. Thompson and Massimo Filippi},
  journal={Multiple Sclerosis},
  year={2008},
  volume={14},
  pages={455 - 464}
}
Although the mechanisms underlying the accumulation of disability in primary progressive (PP) multiple sclerosis (MS) are still unclear, a major role seems to be played by `occult' tissue damage. We investigated whether conventional and magnetization transfer (MT) MRI may provide complementary information for the assessment of PPMS severity. Conventional and MT MRI scans from 226 PPMS patients and 84 healthy controls were collected for centralized analysis. The expanded disability status scale… CONTINUE READING

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