Large ribosomal protein 4 increases efficiency of viral recoding sequences.

@article{Green2012LargeRP,
  title={Large ribosomal protein 4 increases efficiency of viral recoding sequences.},
  author={Lisa Green and Brian Houck-Loomis and Andrew Yueh and Stephen P Goff},
  journal={Journal of virology},
  year={2012},
  volume={86 17},
  pages={
          8949-58
        }
}
Expression of retroviral replication enzymes (Pol) requires a controlled translational recoding event to bypass the stop codon at the end of gag. This recoding event occurs either by direct suppression of termination via the insertion of an amino acid at the stop codon (readthrough) or by alteration of the mRNA reading frame (frameshift). Here we report the effects of a host protein, large ribosomal protein 4 (RPL4), on the efficiency of recoding. Using a dual luciferase reporter assay, we… CONTINUE READING
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