Large proportion of low frequency microsatellite-instability and loss of heterozygosity in pheochromocytoma and endocrine tumors detected with an extended marker panel

@article{Kupka2007LargePO,
  title={Large proportion of low frequency microsatellite-instability and loss of heterozygosity in pheochromocytoma and endocrine tumors detected with an extended marker panel},
  author={Susan Kupka and Birgit Haack and Marty Zdichavsky and Tanja Mlinar and Christine Kienzle and Thomas Bock and Reinhard Kandolf and S Kr{\"o}ber and Alfred Koenigsrainer},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2007},
  volume={134},
  pages={463-471}
}
Pheochromocytoma (PCC) is a usually benign tumor originated in the majority of patients from the adrenal medulla. Regarding sporadic forms of PCC, mechanisms of pathogenesis are largely unknown. Recently, microsatellite-instability (MSI) was discussed as genetic factor contributing to PCC development. Since microsatellite markers used for MSI detection have only been recommended for colorectal carcinoma (CRC), we established an extended marker set for MSI detection in PCC. Twenty-two PCC… CONTINUE READING
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Lack of association between microsatellite instability and benign adrenal tumors

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