Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

@inproceedings{Minciacchi2015LargeOC,
  title={Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles},
  author={Valentina Ren{\`e} Minciacchi and Sungyong You and Cristiana Spinelli and Samantha Morley and Mandana Zandian and Paul-Joseph P. Aspuria and Lorenzo Cavallini and Chiara Ciardiello and Mariana Reis Sobreiro and Matteo Morello and Geetanjali D Kharmate and Su Chul Jang and Dae-Kyum Kim and Elham Hosseini-Beheshti and Emma S. Tomlinson Guns and Martin E. Gleave and Yong Song Gho and S. Mathivanan and Wei Yang and Michael R. Freeman and Dolores Di Vizio},
  booktitle={Oncotarget},
  year={2015}
}
Large oncosomes (LO) are atypically large (1-10 µm diameter) cancer-derived extracellular vesicles (EVs), originating from the shedding of membrane blebs and associated with advanced disease. We report that 25% of the proteins, identified by a quantitative proteomics analysis, are differentially represented in large and nano-sized EVs from prostate cancer cells. Proteins enriched in large EVs included enzymes involved in glucose, glutamine and amino acid metabolism, all metabolic processes… CONTINUE READING

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