Large offspring syndrome in cattle and sheep.

  title={Large offspring syndrome in cattle and sheep.},
  author={Lorraine E. Young and Kevin D Sinclair and Ian Wilmut},
  journal={Reviews of reproduction},
  volume={3 3},
Bovine and ovine embryos exposed to a variety of unusual environments prior to the blastocyst stage have resulted in the development of unusually large offspring which can also exhibit a number of organ defects. In these animals, the increased incidence of difficult parturition and of fetal and neonatal losses has limited the large-scale use of in vitro embryo production technologies commonly used in humans and other species. Four different situations have been identified that result in the… CONTINUE READING
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