Large interindividual variations in metabolism of benzo(alpha)pyrene by peripheral lung tissue from lung cancer patients.

@article{Cohen1979LargeIV,
  title={Large interindividual variations in metabolism of benzo(alpha)pyrene by peripheral lung tissue from lung cancer patients.},
  author={Gerald M. Cohen and Rekha Mehta and M Meredith-Brown},
  journal={International journal of cancer},
  year={1979},
  volume={24 2},
  pages={129-33}
}
A very large variation (44-fold) was observed in the ability of short-term organ cultures of peripheral lung tissue from lung-cancer patients to metabolize the environmental carcinogen benzo(alpha)pyrene to organic solvent-soluble metabolites. The amounts of benzo(alpha)pyrene (2 microM) metabolized ranged from little (1%) to almost total (96.2%) metabolism… CONTINUE READING