Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors

@inproceedings{Timp2014LargeHB,
  title={Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors},
  author={Winston Timp and H{\'e}ctor Corrada Bravo and Oliver G. McDonald and Michael G. Goggins and Chris Umbricht and Martha A. Zeiger and Andrew P. Feinberg and Rafael A. Irizarry},
  booktitle={Genome Medicine},
  year={2014}
}
One of the most provocative recent observations in cancer epigenetics is the discovery of large hypomethylated blocks, including single copy genes, in colorectal cancer, that correspond in location to heterochromatic LOCKs (large organized chromatin lysine-modifications) and LADs (lamin-associated domains). Here we performed a comprehensive genome-scale analysis of 10 breast, 28 colon, nine lung, 38 thyroid, 18 pancreas cancers, and five pancreas neuroendocrine tumors as well as matched normal… CONTINUE READING
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