Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice.


BACKGROUND Androgen regulation and prostate-specific expression of targeted genes in transgenic mice can be controlled by a small DNA fragment of the probasin (PB) promoter (-426 to +28 base pairs, bp). Although the small PB fragment was sufficient to direct prostate-specific expression, the low levels of transgene expression suggested that important… (More)


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