Large divalent cations and electrostatic potentials adjacent to membranes. Experimental results with hexamethonium.

@article{Alvarez1983LargeDC,
  title={Large divalent cations and electrostatic potentials adjacent to membranes. Experimental results with hexamethonium.},
  author={Osvaldo Alvarez and Malcolm S. Brodwick and Ramon Latorre and Alan Mclaughlin and S Mclaughlin and G{\'a}bor Szab{\'o}},
  journal={Biophysical journal},
  year={1983},
  volume={44 3},
  pages={
          333-42
        }
}
A simple extension of the Gouy-Chapman theory predicts that the ability of a divalent cation to screen charges at a membrane-solution interface decreases significantly if the distance between the charges on the cation is comparable with the Debye length. We tested this prediction by investigating the effect of hexamethonium on the electrostatic potential adjacent to negatively charged phospholipid bilayer membranes. The distance between the two charges of an extended hexamethonium molecule is… CONTINUE READING
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