Large depolarization induces long openings of voltage-dependent calcium channels in adrenal chromaffin cells.

@article{Hoshi1987LargeDI,
  title={Large depolarization induces long openings of voltage-dependent calcium channels in adrenal chromaffin cells.},
  author={Toshinori Hoshi and Stephen M Smith},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1987},
  volume={7 2},
  pages={
          571-80
        }
}
Single Ca2+-channel currents in bovine adrenal chromaffin cells were studied with the patch-clamp technique using Ba2+ as the charge carrier. Depolarizing pulses to voltages less than +10 mV from holding voltage of -60 mV elicited short openings with a mean life time of less than 1 msec. Depolarization to more positive voltages elicited longer openings with a mean life time of about 3 msec in addition to the short openings similar to those observed at less positive voltages. Following large… CONTINUE READING
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