Large dense-core vesicles in rat adrenal after reserpine: levels of mRNAs of soluble and membrane-bound constituents in chromaffin and ganglion cells indicate a biosynthesis of vesicles with higher secretory quanta.

@article{Laslop1994LargeDV,
  title={Large dense-core vesicles in rat adrenal after reserpine: levels of mRNAs of soluble and membrane-bound constituents in chromaffin and ganglion cells indicate a biosynthesis of vesicles with higher secretory quanta.},
  author={Andrea Laslop and Sushil K Mahata and M Wolkersdorfer and Manjula Mahata and Madhulika Srivastava and Nabil G Seidah and Reiner Fischer-Colbrie and Heinz Winkler},
  journal={Journal of neurochemistry},
  year={1994},
  volume={62 6},
  pages={2448-56}
}
Rats were injected with a large dose of reserpine known to stimulate the adrenal medulla. Various times after drug treatment the mRNA levels of several constituents of large dense-core vesicles were determined by northern blot analysis and in situ hybridization. The latter method allowed detection of changes in mRNA levels not only in chromaffin cells, but also in the ganglion cells found in adrenal medulla. Levels of the mRNAs of secretory components of large dense-core vesicles (chromogranins… CONTINUE READING

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