Large conductance Ca(2+)-activated K+ channels are involved in both spike shaping and firing regulation in Helix neurones.

@article{Crest1993LargeCC,
  title={Large conductance Ca(2+)-activated K+ channels are involved in both spike shaping and firing regulation in Helix neurones.},
  author={Marcel Crest and Maurice Gola},
  journal={The Journal of physiology},
  year={1993},
  volume={465},
  pages={265-87}
}
1. The role of BK-type calcium-dependent K+ channels (K+Ca) in cell firing regulation was evaluated by performing whole-cell voltage clamp and patch clamp experiments on the U cell neurones in the snail Helix pomatia. These cells were selected because most of the repolarizing K+ current flowed through K+Ca channels. 2. U cells generated overshooting Ca(2+)-dependent spikes in Na(+)-free saline. In response to prolonged depolarizing current, they fired a limited number of spikes of decreasing… CONTINUE READING

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