Large-cell neuroendocrine carcinoma with epidermal growth factor receptor mutation: possible transformation of lung adenocarcinoma.

@article{Yanagisawa2012LargecellNC,
  title={Large-cell neuroendocrine carcinoma with epidermal growth factor receptor mutation: possible transformation of lung adenocarcinoma.},
  author={Satoru Yanagisawa and Naoto Morikawa and Yuichiro Kimura and Yoko Nagano and Kazuhiro Murakami and Toshiharu Tabata},
  journal={Respirology},
  year={2012},
  volume={17 8},
  pages={1275-7}
}
Mutations in the epidermal growth factor receptor (EGFR) occur in approximately 10% of patients with non-small-cell lung carcinoma, especially those with adenocarcinoma. Although EGFR-tyrosine kinase inhibitors (EGFR-TKI) are an effective treatment for these carcinomas, emerging drug resistance is a problem that remains unsolved. This has been partly explained by a second EGFR mutation or amplification of the MET (hepatocyte growth factor receptor) gene; however, histological transformation to… CONTINUE READING

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