Large-cell neuroendocrine carcinoma of the lung: surgical management.


Large-cell neuroendocrine carcinoma (LCNEC) of the lung is an uncommon aggressive neoplasm with a poor prognosis compared with non-small-cell lung carcinoma (NSCLC). Because of its rarity, the treatment recommendations are not based on clinical trials, but are extrapolated from the approach to patients with NSCLC and small-cell lung carcinoma and the established literature for LCNEC, which is primarily retrospective in nature. Further studies should clarify the histology-specific characteristic and optimal therapeutic approach to establish the entity of LCNEC.

DOI: 10.1016/j.thorsurg.2014.05.001
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@article{Sakurai2014LargecellNC, title={Large-cell neuroendocrine carcinoma of the lung: surgical management.}, author={Hiroyuki Sakurai and Hisao Asamura}, journal={Thoracic surgery clinics}, year={2014}, volume={24 3}, pages={305-11} }