Large bowel stenosis in rats after fractionated local irradiation.

@article{Kiszel1984LargeBS,
  title={Large bowel stenosis in rats after fractionated local irradiation.},
  author={Z Kiszel and Andreas Spiethoff and K. R. Trott},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={1984},
  volume={2 3},
  pages={247-54}
}
After local irradiation of the distal large bowel rats may develop fatal large bowel stenosis within 200 days. The incidence rises steeply with dose. The LD50 for single dose irradiation is 20 Gy. The tolerance of the large bowel to local irradiation depends strongly on dose fractionation. Extending the intervals between the fractions and decreasing the… CONTINUE READING