Large animal models of traumatic injury to the immature brain.

  title={Large animal models of traumatic injury to the immature brain.},
  author={A G Duhaime},
  journal={Developmental neuroscience},
  volume={28 4-5},
  • A G Duhaime
  • Published 2006 in Developmental neuroscience
Large animal models have been used much less frequently than rodent models to study traumatic brain injury. However, large animal models offer distinct advantages in replicating specific mechanisms, morphology and maturational stages relevant to age-dependent injury responses. This paper reviews how each of these features is relevant in matching a model to a particular scientific question and discusses various scaling strategies, advantages and disadvantages of large animal models for studying… CONTINUE READING

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