Large-animal models of fulminant hepatic failure

  title={Large-animal models of fulminant hepatic failure},
  author={Yoshihiro Takada and Shingo Ishiguro and Kiyoshi Fukunaga},
  journal={Journal of Artificial Organs},
 For the development of an artificial liver support system, a clinically relevant large-animal model of fulminant hepatic failure (FHF) is indispensable. Although several large-animal models have been reported so far, they have not been entirely satisfactory. Recently, we have developed a new porcine model of FHF by means of intraportal administration of 0… CONTINUE READING