Large-Scale Proteomics Differentiates Cholesteatoma from Surrounding Tissues and Identifies Novel Proteins Related to the Pathogenesis

@inproceedings{Britze2014LargeScalePD,
  title={Large-Scale Proteomics Differentiates Cholesteatoma from Surrounding Tissues and Identifies Novel Proteins Related to the Pathogenesis},
  author={Anders Faarup Britze and Rune Isak Dupont Birkler and Niels Gregersen and Therese Ovesen and Johan Palmfeldt},
  booktitle={PloS one},
  year={2014}
}
Cholesteatoma is the growth of keratinizing squamous epithelium in the middle ear. It is associated with severe complications and has a poorly understood etiopathogenesis. Here, we present the results from extensive bioinformatics analyses of the first large-scale proteomic investigation of cholesteatoma. The purpose of this study was to take an unbiased approach to identifying alterations in protein expression and in biological processes, in order to explain the characteristic phenotype of… CONTINUE READING
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