Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

  title={Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia},
  author={R. David Hawkins and Stavros Bashiardes and Kara E Powder and Samin A Sajan and Veena Bhonagiri and David M. Alvarado and Judith D. Speck and Mark E. Warchol and Michael Lovett},
  journal={PLoS ONE},
  pages={947 - 950}
Loss of inner ear sensory hair cells (HC) is a leading cause of human hearing loss and balance disorders. Unlike mammals, many lower vertebrates can regenerate these cells. We used cross-species microarrays to examine this process in the avian inner ear. Specifically, changes in expression of over 1700 transcription factor (TF) genes were investigated in hair cells of auditory and vestibular organs following treatment with two different damaging agents and regeneration in vitro. Multiple… CONTINUE READING


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