Large-Scale Discovery of Gene-Enriched SNPs

  title={Large-Scale Discovery of Gene-Enriched SNPs},
  author={Michael A Gore and Mark H. Wright and Elhan S. Ersoz and Pascal Bouffard and Edward S. Szekeres and Thomas P. Jarvie and Bonnie L. Hurwitz and Apurva Narechania and Timothy T. Harkins and George S. Grills and Doreen H Ware and Edward S. Buckler},
Whole-genome association studies of complex traits in higher eukaryotes require a high density of single nucleotide polymorphism (SNP) markers at genome-wide coverage. To design high-throughput, multiplexed SNP genotyping assays, researchers must fi rst discover large numbers of SNPs by extensively resequencing multiple individuals or lines. For SNP discovery approaches using short read-lengths that nextgeneration DNA sequencing technologies offer, the highly repetitive and duplicated nature of… CONTINUE READING
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