Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4

@inproceedings{Allen2015LargeScaleCS,
  title={Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4},
  author={Bryce K. Allen and Saurabh Mehta and Stewart W. J. Ember and Ernst Schonbrunn and Nagi George Ayad and Stephan C. Sch{\"u}rer},
  booktitle={Scientific reports},
  year={2015}
}

• Bryce K. Allen, Saurabh Mehta, +3 authors Stephan C. Schürer
• Published 2015 in Scientific reports
• DOI:10.1038/srep16924

Inhibition of cancer-promoting kinases is an established therapeutic strategy for the treatment of many cancers, although resistance to kinase inhibitors is common. One way to overcome resistance is to target orthogonal cancer-promoting pathways. Bromo and Extra-Terminal (BET) domain proteins, which belong to the family of epigenetic readers, have recently emerged as promising therapeutic targets in multiple cancers. The development of multitarget drugs that inhibit kinase and BET proteins… CONTINUE READING

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