Large-Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology

@inproceedings{Grubbs2017LargeScaleBA,
  title={Large-Scale Bioinformatics Analysis of Bacillus Genomes Uncovers Conserved Roles of Natural Products in Bacterial Physiology},
  author={Kirk J. Grubbs and Rachel M. Bleich and Kevin C Santa Maria and Scott E. Allen and Sherif Farag and Elizabeth A. Shank and Albert A Bowers},
  booktitle={mSystems},
  year={2017}
}
Bacteria possess an amazing capacity to synthesize a diverse range of structurally complex, bioactive natural products known as specialized (or secondary) metabolites. Many of these specialized metabolites are used as clinical therapeutics, while others have important ecological roles in microbial communities. The biosynthetic gene clusters (BGCs) that generate these metabolites can be identified in bacterial genome sequences using their highly conserved genetic features. We analyzed an… CONTINUE READING
36
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES