Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques

@inproceedings{Kim2011LargeScaleBS,
  title={Large-Scale Bi-Level Strain Design Approaches and Mixed-Integer Programming Solution Techniques},
  author={Joonhoon Kim and Jennifer L. Reed and Christos T. Maravelias},
  booktitle={PloS one},
  year={2011}
}
The use of computational models in metabolic engineering has been increasing as more genome-scale metabolic models and computational approaches become available. Various computational approaches have been developed to predict how genetic perturbations affect metabolic behavior at a systems level, and have been successfully used to engineer microbial strains with improved primary or secondary metabolite production. However, identification of metabolic engineering strategies involving a large… CONTINUE READING

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Rational design of efficient modular cells.

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