Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing

@inproceedings{Ali2011LargeScaleAO,
  title={Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing},
  author={Shaukat Ali and Harald G. J. van Mil and Michael Richardson},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND In the drug discovery pipeline, safety pharmacology is a major issue. The zebrafish has been proposed as a model that can bridge the gap in this field between cell assays (which are cost-effective, but low in data content) and rodent assays (which are high in data content, but less cost-efficient). However, zebrafish assays are only likely to be useful if they can be shown to have high predictive power. We examined this issue by assaying 60 water-soluble compounds representing a… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish

  • IW Selderslaghs, AR Van Rompay, CW De, HE Witters
  • embryo. Reprod Toxicol
  • 2009
2 Excerpts

Similar Papers

Loading similar papers…