Large-Scale Analysis of Disease Pathways in the Human Interactome

@article{Agrawal2017LargeScaleAO,
  title={Large-Scale Analysis of Disease Pathways in the Human Interactome},
  author={Monica Agrawal and Marinka Zitnik and Jure Leskovec},
  journal={bioRxiv},
  year={2017}
}
Discovering disease pathways, which can be defined as sets of proteins associated with a given disease, is an important problem that has the potential to provide clinically actionable insights for disease diagnosis, prognosis, and treatment. Computational methods aid the discovery by relying on protein-protein interaction (PPI) networks. They start with a few known disease-associated proteins and aim to find the rest of the pathway by exploring the PPI network around the known disease proteins… 

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