Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity

@inproceedings{Koekemoer2017LargeScaleAO,
  title={Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity},
  author={Andrea L. Koekemoer and Veryan Codd and Nicholas G. D. Masca and Christopher P Nelson and Muntaser D. Musameh and Bernhard M Kaess and Christian Hengstenberg and Daniel J. Rader and Nilesh J. Samani},
  booktitle={Arteriosclerosis, thrombosis, and vascular biology},
  year={2017}
}
OBJECTIVE Cholesterol efflux capacity (CEC) has emerged as a biomarker of coronary artery disease risk beyond plasma high-density lipoprotein (HDL) cholesterol (HDL-C) level. However, the determinants of CEC are incompletely characterized. We undertook a large-scale family-based population study to identify clinical, biochemical, and HDL particle parameter determinants of CEC, characterize reasons for the discordancy with HDL-C, quantify its heritability, and assess its stability over 10 to 12… CONTINUE READING
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