Large-Scale Analysis of B-Cell Epitopes on Influenza Virus Hemagglutinin – Implications for Cross-Reactivity of Neutralizing Antibodies

@inproceedings{Sun2014LargeScaleAO,
  title={Large-Scale Analysis of B-Cell Epitopes on Influenza Virus Hemagglutinin – Implications for Cross-Reactivity of Neutralizing Antibodies},
  author={Jing Sun and Ulrich Johan Kudahl and Christian Simon and Zhiwei W. Cao and Ellis L. Reinherz and Vladimir Brusic},
  booktitle={Front. Immunol.},
  year={2014}
}
Influenza viruses continue to cause substantial morbidity and mortality worldwide. Fast gene mutation on surface proteins of influenza virus result in increasing resistance to current vaccines and available antiviral drugs. Broadly neutralizing antibodies (bnAbs) represent targets for prophylactic and therapeutic treatments of influenza. We performed a systematic bioinformatics study of cross-reactivity of neutralizing antibodies (nAbs) against influenza virus surface glycoprotein hemagglutinin… CONTINUE READING
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