Large CAG/CTG repeats are associated with childhood-onset schizophrenia

@article{Burgess1998LargeCR,
  title={Large CAG/CTG repeats are associated with childhood-onset schizophrenia},
  author={Catherine Elizabeth Burgess and Kerstin Lindblad and Ellen Sidransky and Q-P Yuan and Robert T.L. Long and Theresa S. Breschel and Christopher A. Ross and Melvin McInnis and Peter Wankyoon Lee and EdwardI. Ginns and Marge C Lenane and Sanjiv Kumra and Leslie N Jacobsen and Judith L. Rapoport and Martin Schalling},
  journal={Molecular Psychiatry},
  year={1998},
  volume={3},
  pages={321-327}
}
Recent studies have shown an association between trinucleotide repeat expansions (TREs) and adult-onset schizophrenia (AOS). Childhood-onset schizophrenia (COS) is a severe variant of schizophrenia with onset of symptoms before age 12 years. We have used the repeat expansion detection (RED) method to investigate the occurrence of repeat expansions in a group of well-characterized COS patients as well as a set of clinically related childhood-onset psychosis cases labeled ‘multidimensionally… CONTINUE READING
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References

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