Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery

@article{Roemer2003LargescaleEG,
  title={Large‐scale essential gene identification in Candida albicans and applications to antifungal drug discovery},
  author={Terry Roemer and Bo Jiang and John Davison and Troy Ketela and Karynn Veillette and Anouk Breton and Fatoumata Tandia and Annie Linteau and Susan Sillaots and Catarina Marta and Nick Martel and Steeve V{\'e}ronneau and S{\'e}bastien Lemieux and Sarah J Kauffman and Jeffrey M. Becker and Reginald Storms and Charles Boone and Howard Bussey},
  journal={Molecular Microbiology},
  year={2003},
  volume={50}
}
Candida albicans is the primary fungal pathogen of humans. Despite the need for novel drugs to combat fungal infections [Sobel, J.D. (2000) Clin Infectious Dis 30: 652], antifungal drug discovery is currently limited by both the availability of suitable drug targets and assays to screen corresponding targets. A functional genomics approach based on the diploid C. albicans genome sequence, termed GRACETM (gene replacement and conditional expression), was used to assess gene essentiality through… Expand
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