Lapatinib: a novel dual tyrosine kinase inhibitor with activity in solid tumors.

@article{Nelson2006LapatinibAN,
  title={Lapatinib: a novel dual tyrosine kinase inhibitor with activity in solid tumors.},
  author={Michael H. Nelson and Christian R Dolder},
  journal={The Annals of pharmacotherapy},
  year={2006},
  volume={40 2},
  pages={261-9}
}
OBJECTIVE To review the pharmacology, pharmacokinetics, clinical trials, adverse effects, and drug interactions of lapatinib. DATA SOURCES A PubMed search was conducted (1966-August 2005) using the following terms: lapatinib, GW572016, and dual tyrosine kinase inhibitor. Additional information sources included meeting abstracts, clinical trial data, and bibliographies from articles identified through PubMed. STUDY SELECTION AND DATA EXTRACTION Preclinical and clinical trials that evaluated… CONTINUE READING