• Corpus ID: 53124023

Lapachol and Its D erivatives as Potential D rug s for C an cer T reatment

@inproceedings{Nepomuceno2016LapacholAI,
  title={Lapachol and Its D erivatives as Potential D rug s for C an cer T reatment},
  author={Júlio César Nepomuceno},
  year={2016}
}
Natural products extracted from plants have significantly contributed to the development of various medications used clinically in traditional medicine (Newman et al., 2003). Prospection of biological materials in plants, in areas of wide biodiversity in tropical and subtropical regions, provides chemical diversity for obtaining products for the development of new drugs (Kinghorn et al., 2003). Natural products have been widely used in treatment of diseases in popular medicine. Based on this… 
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References

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An in vitro assay using the murine erythroleukemia (clone 3-1) cells for the analysis of antineoplastic activity in natural products and indicates the presence of lapachol, a vitamin K antagonist that might target such vitamin K-dependent reactions as the activation of a ligand for the Axl receptor tyrosine kinase.

Lapachol: An overview

The interesting and most usefull knowledge on lapachol, which is reviewed in this paper, can be used as a starting point in future research endeavors.

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The volatile essential oils of commonly used culinary herbs, spices, and herbal teas inhibit mevalonate synthesis and thereby suppress cholesterol synthesis and tumor growth.

Demonstration of the lapachol as a potential drug for reducing cancer metastasis.

This study aims to examine the molecular and morphological alterations caused by lapachol treatment, as well as its effects on the intrinsic tissue invasive property of HeLa cells in CAM model, and concludes that Lapachol has a great potential of application in fighting metastasis.

Sulindac Compounds Facilitate the Cytotoxicity of β-Lapachone by Up-Regulation of NAD(P)H Quinone Oxidoreductase in Human Lung Cancer Cells

Sulindac and its metabolites synergistically increase the anticancer effects of β-lapachone primarily by increasing NQO1 activity and expression, and these two drugs may provide a novel combination therapy for lung cancers.

LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells

The data suggest that LQB-118 has a potent anti-CML activity that can overcome multifactorial drug resistance mechanisms, making this compound a promising new anti- CML agent.

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From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.

The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1

The finding that β-lapachone has IDO1 inhibitory activity adds a new dimension to its potential utility as an anti-cancer agent distinct from its cytotoxic properties, and suggests that a synergistic benefit can be achieved from its combined cytot toxic and immunologic effects.

Lapachol as an epithelial tumor inhibitor agent in Drosophila melanogaster heterozygote for tumor suppressor gene wts.

Evaluated the antitumoral effects of lapachol by testing for clones of epithelial tumors in Drosophila melanogaster and found it did significantly reduce the number of tumors provoked by doxorubicin.
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