Lantibiotic biosynthesis: interactions between prelacticin 481 and its putative modification enzyme, LctM.

@article{Uguen2000LantibioticBI,
  title={Lantibiotic biosynthesis: interactions between prelacticin 481 and its putative modification enzyme, LctM.},
  author={Patricia Uguen and Jean-Paul Le Pennec and Alain Dufour},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 18},
  pages={
          5262-6
        }
}
Class AII and AIII lantibiotics and mersacidin are antibacterial peptides containing unusual residues obtained by posttranslational modifications of prepeptides, presumably catalyzed by LanM. LctM, the LanM for lacticin 481, is essential for the production of this class AII lantibiotic. Using the yeast two-hybrid system, we showed direct contact between the prelacticin 481 and LctM, supporting the proposed LctM function. Sixteen domains are conserved between the 10 known LanM proteins, whereas… CONTINUE READING

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