Lanthanum Potentiates GABA-Activated Currents in Rat Pyramidal Neurons of CA1 Hippocampal Field

@article{Boldyreva2005LanthanumPG,
  title={Lanthanum Potentiates GABA-Activated Currents in Rat Pyramidal Neurons of CA1 Hippocampal Field},
  author={A. Boldyreva},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2005},
  volume={140},
  pages={403-405}
}
  • A. Boldyreva
  • Published 2005
  • Chemistry, Medicine
  • Bulletin of Experimental Biology and Medicine
  • In CA1 hippocampal pyramidal neurons, lanthanum ions increased the amplitude of GABA-activated currents and shifted the dose-dependence curve to the left, which attests to increased affinity of GABAA-receptors to GABA. The data made it possible to compare the sensitivity GABAA-receptors of pyramidal neurons and similar receptors of other cells to GABA and lanthanum. 
    12 Citations

    Figures and Topics from this paper

    Molecular neurochemistry of the lanthanides
    • 4
    • PDF
    Metal Toxicity at the Synapse: Presynaptic, Postsynaptic, and Long-Term Effects
    • 54
    • PDF
    jneumeth new cross-correlation algorithm for the analysis of “ in vitro ” neuronal network ctivity aimed at pharmacological studies
    • A. Menegonb, G. Regaliaa, S. Maidab, G. Ferrignoa, A. Pedrocchia
    • 2011

    References

    SHOWING 1-10 OF 12 REFERENCES
    Modulation of GABA-Activated Currents in Rat Isolated Cerebellar Neurons by Lanthanum Ions
    • S. N. Kolbaev
    • Chemistry, Medicine
    • Bulletin of Experimental Biology and Medicine
    • 2004
    • 4
    Enhancement of gamma-aminobutyric acid-activated chloride channel currents by lanthanides in rat dorsal root ganglion neurons
    • J. Ma, T. Narahashi
    • Chemistry, Medicine
    • The Journal of neuroscience : the official journal of the Society for Neuroscience
    • 1993
    • 31
    • PDF
    From GABAA receptor diversity emerges a unified vision of GABAergic inhibition.
    • E. Costa
    • Biology, Medicine
    • Annual review of pharmacology and toxicology
    • 1998
    • 145
    Vibrodissociation of sliced mammalian nervous tissue
    • 169