Lanthanum Potentiates GABA-Activated Currents in Rat Pyramidal Neurons of CA1 Hippocampal Field

  title={Lanthanum Potentiates GABA-Activated Currents in Rat Pyramidal Neurons of CA1 Hippocampal Field},
  author={A. A. Boldyreva},
  journal={Bulletin of Experimental Biology and Medicine},
  • A. A. Boldyreva
  • Published 1 October 2005
  • Biology
  • Bulletin of Experimental Biology and Medicine
In CA1 hippocampal pyramidal neurons, lanthanum ions increased the amplitude of GABA-activated currents and shifted the dose-dependence curve to the left, which attests to increased affinity of GABAA-receptors to GABA. The data made it possible to compare the sensitivity GABAA-receptors of pyramidal neurons and similar receptors of other cells to GABA and lanthanum. 
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  • S. N. Kolbaev
  • Biology, Chemistry
    Bulletin of Experimental Biology and Medicine
  • 2004
Lanthanum ions (10-1000 μM) potentiated GABA-activated currents and increased the sensitivity of GABAA receptors in isolated Purkinje cells from rat cerebellum. GABA receptors in Purkinje cells are
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  • Jy Ma, T. Narahashi
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1993
Lanthanum was previously reported to potentiate the GABA-induced chloride currents reversibly by acting at a distinct site on the GABAA receptor-channel complex, but all other lanthanides tested enhanced the GABA responses with greater efficiencies and produced inward currents by themselves.
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Consistent with the heterogeneity of expression of GABAR subunit mRNA and protein in the hippocampus and based on their differential responses to GABA and to allosteric modulators, distinct populations of CA1 pyramidal cells likely express multiple, functional GABar isoforms.
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  • E. Costa
  • Biology
    Annual review of pharmacology and toxicology
  • 1998
GAB potency variability, which emerges from GABAA receptor diversity, plays a unifying role in the intrinsic functional mechanism of laminated structures, which is a mechanism operative in neuronal circuit adaptation to the extreme amplification of GABA-gated Cl- current intensities.
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