Lanthanum: Inhibition of Acth-stimulated Cyclic Amp and Corticosterone Synthesis in Isolated Rat Adrenocortical Cells

  • Published 2003
Lanthanum (La +++) is a well-known Ca ++ antagonist in a number of biological systems. It was used in the present study to examine the role of Ca ++ in the regulation of adenyl cyclase of the adrenal cortex by ACTH. In micromolar concentrations, La +++ inhibited both cyclic AMP and corticosterone response of isolated adrenal cortex cells to ACTH. However, a… CONTINUE READING