Language lateralization and handedness in women prenatally exposed to diethylstilbestrol (DES)

@article{Smith2000LanguageLA,
  title={Language lateralization and handedness in women prenatally exposed to diethylstilbestrol (DES)},
  author={Laurel L Smith and Melissa Hines},
  journal={Psychoneuroendocrinology},
  year={2000},
  volume={25},
  pages={497-512}
}
Hand preferences and language lateralization were assessed in women exposed prenatally to the synthetic estrogen, diethylstilbestrol (DES), and in their unexposed sisters. The DES-exposed women showed an increased degree of hand preference (regardless of direction) and were more likely to be left handed for writing. However, the groups did not differ significantly on a dichotic listening measure of language lateralization. Perhaps as a result of the alterations in hand preferences, the typical… 
Androgenic influences on neural asymmetry: Handedness and language lateralization in individuals with congenital adrenal hyperplasia
TLDR
Results do not support the hypothesis that prenatal androgens influence language lateralization, nor do they support the Geschwind-Behan-Galaburda model that posits a key role for testosterone in the development of cognitive problems in males, secondary to changes in hemispheric development and cognitive lateralization.
Differential effects of prenatal testosterone on lateralization of handedness and language.
TLDR
The analysis shows that pT has quite stronger explanatory power than sex by itself, although there may be an additional effect of sex independent from pT, which implies a differential effect of pT on language lateralization and handedness.
Sex specific effect of prenatal testosterone on language lateralization in children
TLDR
A clear relationship between prenatal levels of testosterone as assessed from amniotic fluid of healthy pregnant mothers and language lateralization of their offspring at the age of 6 years is demonstrated and suggests that in girls higher prenatal testosterone exposure facilitates left hemisphere language processing, whereas in boys it reduces the information transfer via the corpus callosum.
Salivary testosterone levels are unrelated to handedness or cerebral lateralization for language
TLDR
The present study investigated hormonal effects on laterality using adult salivary T levels, to explore the adequacy of competing theories: the Geschwind, Behan and Galaburda, the callosal, and the sexual differentiation hypotheses.
An examination of the influence of prenatal sex hormones on handedness: Literature review and amniotic fluid data
Competing theories have posited roles for foetal androgen exposure in the development of human handedness. However, due to practical and ethical considerations, few studies have used hormonal
Salivary testosterone is related to both handedness and degree of linguistic lateralization in normal women
TLDR
Test of the hypothesis that individual differences in testosterone (T) are associated with different patterns of linguistic lateralization and hand preference found a pattern emerged in that RH-strongly lateralized and LH-weakly lateralization women showed similar T levels.
No association between adult sex steroids and hand preference in humans.
  • Thomas Richardson
  • Medicine
    American journal of human biology : the official journal of the Human Biology Council
  • 2021
TLDR
The testosterone and estradiol levels of left- and mixed-handed adults are no different to those of right-handers, which has implications for studies that show elevated risk of hormonal-related mental and physical disorders in left-handed individuals.
Sex differences in handedness, asymmetry of the Planum Temporale and functional language lateralization
TLDR
In conclusion, males are more frequently non-right handed than females, but there is no sex difference in asymmetries of the Planum Temporale, dichotic listening or functional imaging findings during language tasks.
Psychosexual Characteristics of Men and Women Exposed Prenatally to Diethylstilbestrol
TLDR
Overall, the findings provide little support for the hypothesis that prenatal exposure to DES influences the psychosexual characteristics of adult men and women.
Serious psychiatric outcome of subjects prenatally exposed to diethylstilboestrol in the E3N cohort study
TLDR
The findings suggest that the impact of prenatal DES exposure on foetal brain development, if any, is unlikely to increase the risk of serious psychiatric disorders.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 69 REFERENCES
Handedness and other laterality indices in women prenatally exposed to DES.
TLDR
It was concluded that intrauterine exposure to the synthetic estrogen DES disturbs the normal process of cerebral lateralization and laterality indices and the mechanism by which this takes place is still unknown.
Sexual Differentiation of Cognitive Abilities in Women Exposed to Diethylstilbestrol (DES) Prenatally
TLDR
Results support the conclusion that prenatal exposure to DES has little or no influence on cognitive development in women and do not preclude other types of early hormonal influences on human cognition, such as prenatal influences of androgen or influences ofandrogens or estrogens during the early postnatal period.
Handedness in women with intrauterine exposure to diethylstilbestrol
TLDR
The handedness distribution in the DES daughters was significantly shifted away from strong righthandedness compared with the handedness distributed in the controls, and aspects of handedness measurement are discussed.
The influence of sex and handedness in the hemispheric specialization of verbal and nonverbal tasks
TLDR
It was found that handedness, familial sinistrality and sex all affect hemispheric specialization, however, the effects of these factors differed according to the task involved.
Prenatal estrogens and the development of homosexual orientation.
In psychobiological research on sexual orientation, the prenatal hormone theory has a central posi tion. This article examines the hypothesis that prenatal estrogens contribute to the development of
On the magnitude of laterality effects and sex differences in functional lateralities.
  • D. Voyer
  • Psychology, Medicine
    Laterality
  • 1996
TLDR
Results showed that laterality effects tend to be large and significant but that they are heterogeneous in the visual modality, and showed sex differences to be significant in two modalities (visual and auditory).
Handedness and Language Laterality: Discrimination of Handedness Groups on the Dichotic Consonant-Vowel Task
TLDR
Analysis of the relationship of manual preferences for various activities (Edinburgh Handedness Inventory) with DCVT REAs showed that right hand preferences were associated with REAs across groups for most Edinburgh items during the second half of the trials, shown to be strongest in the left handed Ss.
Functional cerebral asymmetry and sexual orientation in men and women.
TLDR
The finding of an association between aspects of functional asymmetry, a neurological characteristics likely present from birth, and sexual orientation suggests that a neurobiological factor is involved in the origins of sexual orientation.
Left-handedness: Behavioral implications and anomalies.
Birth Stress and Intrauterine Factors . Birth Stress and Left-Handedness: The Rare Trait Marker Model (S. Coren and A. Searleman). Non Right-Handedness and the Continuum of Reproductive Casualty (P.
Estrogenic contributions to sexual differentiation in the female guinea pig: Influences of diethylstilbestrol and tamoxifen on neural, behavioral, and ovarian development
TLDR
The results suggest that estrogens play a substantial role in sexual differentiation in the guinea pig, and unusually low levels may impair some aspects of both masculine-Typical and feminine-typical development.
...
1
2
3
4
5
...