Language fMRI abnormalities associated with FOXP2 gene mutation

@article{Ligeois2003LanguageFA,
  title={Language fMRI abnormalities associated with FOXP2 gene mutation},
  author={Fr{\'e}d{\'e}rique J Li{\'e}geois and Torsten Baldeweg and Alan Connelly and David G. Gadian and Mortimer M. Mishkin and Faraneh Vargha-Khadem},
  journal={Nature Neuroscience},
  year={2003},
  volume={6},
  pages={1230-1237}
}
Half the members of the KE family suffer from a speech and language disorder caused by a mutation in the FOXP2 gene. [] Key Method We examined functional brain abnormalities associated with this mutation using two fMRI language experiments, one involving covert (silent) verb generation and the other overt (spoken) verb generation and word repetition. The unaffected family members showed a typical left-dominant distribution of activation involving Broca's area in the generation tasks and a more bilateral…

Endophenotypes of FOXP2: dysfunction within the human articulatory network.

Neocerebellar Crus I Abnormalities Associated with a Speech and Language Disorder Due to a Mutation in FOXP2

TLDR
It is shown that right Crus I volume correlates with left and total caudate nucleus volumes in affected KE members, and that right and total Crus I volumes predict the performance of affected members in non-word repetition and non-verbal orofacial praxis.

Identification of FOXP2 truncation as a novel cause of developmental speech and language deficits.

TLDR
Investigation of the entire coding region of FOXP2, including alternatively spliced exons, in 49 probands affected with verbal dyspraxia and the discovery of the first nonsense mutation in FoxP2 opens the door for detailed investigations of neurodevelopment in people carrying different etiological variants of the gene.

Functional genetic analysis of mutations implicated in a human speech and language disorder.

TLDR
It is hypothesize that expression of alternative isoforms of FOXP2 may provide mechanisms for post-translational regulation of transcription factor function, and explore the properties of different isoforms, resulting from alternative splicing in human brain.

Phonological working memory and FOXP2

Assessing the effects of common variation in the FOXP2 gene on human brain structure

TLDR
The impact of this gene on brain structure may be largely limited to extreme cases of rare disruptive alleles, and effects of common variants at this gene exist but are too subtle to be detected with standard volumetric techniques.

Early neuroimaging markers of FOXP2 intragenic deletion

TLDR
It is concluded that FOXP2 anomaly is either directly or indirectly associated with atypical development of widespread subcortical networks early in life.

Developmental disorders of speech and language: from genes to brain structure and function.

  • K. Watkins
  • Psychology, Biology
    Progress in brain research
  • 2011
...

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