Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

  title={Langerin is a natural barrier to HIV-1 transmission by Langerhans cells},
  author={L. Witte and A. Nabatov and M. Pion and D. Fluitsma and M. A. D. Jong and T. D. Gruijl and V. Piguet and Y. Kooyk and T. Geijtenbeek},
  journal={Nature Medicine},
  • L. Witte, A. Nabatov, +6 authors T. Geijtenbeek
  • Published 2007
  • Biology, Medicine
  • Nature Medicine
  • Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells (LCs) are the first DC subset to encounter HIV-1. It has generally been assumed that LCs mediate the transmission of HIV-1 to T cells through the C-type lectin Langerin, similarly to transmission by DC… CONTINUE READING
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