Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

@article{Witte2007LangerinIA,
  title={Langerin is a natural barrier to HIV-1 transmission by Langerhans cells},
  author={Lot D. de Witte and Alexey A. Nabatov and Marjorie Pion and Donna M. Fluitsma and Marein A.W.P. de Jong and Tanja D. de Gruijl and Vincent Piguet and Yvette Kooyk and Teunis B. H. Geijtenbeek},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={367-371}
}
Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells (LCs) are the first DC subset to encounter HIV-1. It has generally been assumed that LCs mediate the transmission of HIV-1 to T cells through the C-type lectin Langerin, similarly to transmission by DC… Expand
Distinct roles for DC-SIGN+-dendritic cells and Langerhans cells in HIV-1 transmission.
TLDR
The molecular mechanisms involved in HIV-1 transmission and viral clearance are discussed and a better understanding of these processes is crucial to understand and develop strategies to combat transmission. Expand
HIV-1 border patrols: Langerhans cells control antiviral responses and viral transmission
TLDR
LCs restrict transmission of CXCR4-using HIV-1 variants, which underscores the role of immature LCs as gatekeepers in the selection of HIV- 1 variants and defines an important role for LC-dendritic cell crosstalk at the periphery in directing adaptive immune responses to viruses. Expand
HIV-1 Replication in Langerhans and Interstitial Dendritic Cells Is Inhibited by Neutralizing and Fc-Mediated Inhibitory Antibodies
TLDR
The results underline the importance of HIV-1 inhibition by the binding of the Fc part of IgGs to Fcγ receptors and suggest that the induction of neutralizing and nonneutralizing inhibitory IgGs in addition to neutralizing IgAs at mucosal sites may contribute to protection against sexual transmission ofAIDS. Expand
Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin
TLDR
These two novel soluble langerin inhibitors could be developed to prevent HIV uptake, infection, and subsequent transfer to T cells during early stages of infection in eLCs and model Mutz-3 LCs. Expand
Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets
TLDR
It is shown that human E3-ubiquitin ligase tri-partite-containing motif 5α (TRIM5α) potently restricts HIV-1 infection of LCs but not of subepithelial DC-SIGN+ DCs, suggesting that therapeutic interventions that incorporate C-type lectin receptors and autophagy-targeting strategies could provide cell-mediated resistance to HIV- 1 in humans. Expand
Human immature Langerhans cells restrict CXCR4-using HIV-1 transmission
TLDR
It is suggested that LCs play a crucial role in R5 selection and that immature LCs effectively restrict X4 at the level of transmission. Expand
Antiviral immune responses by human langerhans cells and dendritic cells in HIV-1 infection.
TLDR
This chapter gives an update on immune responses elicited against viruses and sheds a light on different immune mechanisms that are hijacked by HIV-1 to infect the host. Expand
The role of human dendritic cells in HIV-1 infection.
TLDR
Advances in the role of DCs during HIV-1 infection are summarized and their potential involvement in the development of preventive strategies against HIV- 1 and other sexually transmitted infections are discussed. Expand
Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells
TLDR
The data strongly indicate that BGs belong to the caveolar endocytosis pathway and that caveolin-1 mediated HIV-1 uptake is an intrinsic restriction mechanism present in human LCs that prevents HIV- 1 infection. Expand
Immunological function of Langerhans cells in HIV infection.
TLDR
HIV-primed LCs trigger beneficial immune responses against HIV infection through the increased induction of HIV-specific CD8+ T cells and the decreased induction of effector Tregs in the initial phase of HIV infection, thereby contributing to the prolonged onset of AIDS. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 48 REFERENCES
Candidate Microbicides Block HIV-1 Infection of Human Immature Langerhans Cells within Epithelial Tissue Explants
TLDR
HIV-1 infection in single LCs after exposure to virus within epithelial tissue is document, demonstrate that relatively low numbers of these cells are capable of inducing high levels of infection in cocultured T cells, and provide a useful explant model for testing of agents designed to block sexual transmission of HIV-1. Expand
Diversity of receptors binding HIV on dendritic cell subsets
TLDR
Primary DCs for the receptors involved in viral envelope attachment are characterized and it is observed that C-type lectin receptor (CLR) binding was predominant in skin DCs, whereas binding to emigrating and tonsil DCs was CD4-dependent. Expand
The role of Langerhans cells in the sexual transmission of HIV.
TLDR
There may be multiple ways by which HIV interacts with target cells in the genital mucosa, and this review focuses on the recent advances regarding the cellular events that may occur during heterosexual transmission of HIV. Expand
HIV-1 Selection by Epidermal Dendritic Cells during Transmission across Human Skin
TLDR
Observations suggest that selective infection of the immature epidermal dendritic cells represents the cellular mechanism that limits the initial viremia to HIV-1 that can use the CCR5 coreceptor. Expand
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
TLDR
It is proposed that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells. Expand
R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms
TLDR
Genetic susceptibility data in LCs parallel those of genetic susceptibility studies performed in cohorts of HIV-infected individuals and suggest that CCR5-mediated infection of LCs, and not capture of virus byLCs, provides a biologic basis for understanding certain aspects of host genetic susceptibility to initial HIV infection. Expand
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
TLDR
It is proposed that conjugates of dendritic cells and T cells, as found in the external linings of organs involved in sexual transmission of HIV-1, represent an important site for the productive phase of HIV, providing a mechanism for the chronic depletion of CD4+ memory cells in HIV- 1 disease. Expand
Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells.
TLDR
The controversy of DCs being infected or not infected for the mechanics of viral transfer to CD4+ lymphocytes can be addressed as a function of time. Expand
Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages
  • Deborah Greene Nguyen, J. Hildreth
  • Biology, Medicine
  • European journal of immunology
  • 2003
TLDR
A substantial role for MMR is suggested in the binding and transmission of HIV‐1 by macrophages and this decrease in viral longevity is due to rapid internalization of macrophage‐bound HIV. Expand
HIV‐1 Trafficking to the Dendritic Cell–T‐Cell Infectious Synapse Uses a Pathway of Tetraspanin Sorting to the Immunological Synapse
TLDR
The results indicate that HIV‐1 is internalized into a non‐conventional, non‐lysosomal, endocytic compartment in mDCs and suggest that HIV-1 is able to selectively subvert components of the intracellular trafficking machinery required for formation of the DC–T‐cell immunological synapse to facilitate its own cell‐to‐cell transfer and propagation. Expand
...
1
2
3
4
5
...