Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

@article{Witte2007LangerinIA,
  title={Langerin is a natural barrier to HIV-1 transmission by Langerhans cells},
  author={L. Witte and A. Nabatov and M. Pion and D. Fluitsma and M. A. D. Jong and T. D. Gruijl and V. Piguet and Y. Kooyk and T. Geijtenbeek},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={367-371}
}
  • L. Witte, A. Nabatov, +6 authors T. Geijtenbeek
  • Published 2007
  • Biology, Medicine
  • Nature Medicine
  • Human immunodeficiency virus-1 (HIV-1) is primarily transmitted sexually. Dendritic cells (DCs) in the subepithelium transmit HIV-1 to T cells through the C-type lectin DC-specific intercellular adhesion molecule (ICAM)-3-grabbing nonintegrin (DC-SIGN). However, the epithelial Langerhans cells (LCs) are the first DC subset to encounter HIV-1. It has generally been assumed that LCs mediate the transmission of HIV-1 to T cells through the C-type lectin Langerin, similarly to transmission by DC… CONTINUE READING
    569 Citations
    Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin
    • 29
    • Highly Influenced
    • PDF
    Antiviral immune responses by human langerhans cells and dendritic cells in HIV-1 infection.
    • 21
    The role of human dendritic cells in HIV-1 infection.
    • 43
    Immunological function of Langerhans cells in HIV infection.
    • 7
    Langerhans Cell–Dendritic Cell Cross-Talk via Langerin and Hyaluronic Acid Mediates Antigen Transfer and Cross-Presentation of HIV-1
    • 21
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 48 REFERENCES
    Candidate Microbicides Block HIV-1 Infection of Human Immature Langerhans Cells within Epithelial Tissue Explants
    • 170
    • PDF
    Diversity of receptors binding HIV on dendritic cell subsets
    • 532
    The role of Langerhans cells in the sexual transmission of HIV.
    • 75
    HIV-1 Selection by Epidermal Dendritic Cells during Transmission across Human Skin
    • 181
    • PDF
    R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms
    • 186
    • PDF
    Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages
    • 239