Langerin/CD207 sheds light on formation of birbeck granules and their possible function in langerhans cells

  title={Langerin/CD207 sheds light on formation of birbeck granules and their possible function in langerhans cells},
  author={J. Valladeau and C. Dezutter-Dambuyant and S. Saeland},
  journal={Immunologic Research},
  • J. Valladeau, C. Dezutter-Dambuyant, S. Saeland
  • Published 2003
  • Biology, Medicine
  • Immunologic Research
  • Langerhans cells (LCs) are immature dendritic cells of epidermis and epithelia, playing a sentinel role through their specialized function in antigen capture, and their capacity to migrate to secondary lymphoid tissue to initiate specific immunity. A unique feature of LCs is the presence of Birbeck granules (BGs), which are disks of two limiting membranes, separated by leaflets with periodic “zipperlike” striations. The recent identification of Lagering/CD207 has allowed researchers to decipher… CONTINUE READING
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