Langerin/CD207 sheds light on formation of birbeck granules and their possible function in langerhans cells

@article{Valladeau2003LangerinCD207SL,
  title={Langerin/CD207 sheds light on formation of birbeck granules and their possible function in langerhans cells},
  author={Jenny Valladeau and Colette Dezutter‐Dambuyant and Sem Saeland},
  journal={Immunologic Research},
  year={2003},
  volume={28},
  pages={93-107}
}
Langerhans cells (LCs) are immature dendritic cells of epidermis and epithelia, playing a sentinel role through their specialized function in antigen capture, and their capacity to migrate to secondary lymphoid tissue to initiate specific immunity. A unique feature of LCs is the presence of Birbeck granules (BGs), which are disks of two limiting membranes, separated by leaflets with periodic “zipperlike” striations. The recent identification of Lagering/CD207 has allowed researchers to decipher… Expand
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TLDR
A critical role is reported for the protein annexin A2 (anxA2) in the proper formation of BG structures when anxA2 expression is downregulated, langerin expression decreases, cytoplasmic BG are nearly ablated, and the presence of malformed BG-like structures increases. Expand
Disruption of the langerin/CD207 Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function
TLDR
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TLDR
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Biology of Langerhans cells and Langerhans cell histiocytosis.
TLDR
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Langerin (CD207) Staining in Normal Pediatric Tissues, Reactive Lymph Nodes, and Childhood Histiocytic Disorders
  • K. Chikwava, R. Jaffe
  • Biology, Medicine
  • Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2004
TLDR
It is concluded that Langerin is coexpressed with CD1a on LCs and LCH, and when used alone to confirm LCH infiltration, the 12D6 antibody should be used with caution. Expand
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References

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Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
TLDR
Langerin is a potent inducer of membrane superimposition and zippering leading to BG formation and the data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway. Expand
Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues1
TLDR
Cloned a cDNA-encoding mouse (m)Langerin is cloned, and substitution of a conserved residue within the carbohydrate recognition domain transforms the BG in transfectant cells into structures resembling cored tubules, previously described in mouse LC. Expand
Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates.
TLDR
It is shown that Birbeck granules are not endocytotic structures, rather they are subdomains of the endosomal recycling compartment that form where Langerin accumulates, and implicate ADP-ribosylation factor proteins in LangerIn trafficking and the exchange between Birbeckgranules and other endosome membranes. Expand
Appearance of Birbeck granule-like structures in anti-T6 antibody-treated human epidermal Langerhans cells.
TLDR
By modifying the experimental conditions but retaining the presence of gold-labeled BL6, images that appear to correspond to Birbeck granule-like structures seem to result, at the ultrastructural level, from receptor ligand interactions and from modifications of the LC shape are observed. Expand
Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules
TLDR
Compared to other antigen‐presenting cells, the capacity of human epidermal LC, blood‐derived DC and peripheral blood mononuclear cells to endocytose and present (mannosylated) antigens to antigen‐specific T cells are compared and indicate that LC are relatively inefficient in antigen uptake, processing and presentation. Expand
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TLDR
It is concluded that LCH cells in the bone and/or chronic forms of the disease accumulate within the tissues in an immature state and that most probably result from extrinsic signals and may be induced to differentiate toward mature DCs after CD40 triggering. Expand
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TLDR
It was found that the delimiting membranes of LC granules, both attached to the cytomembrane and in the cytoplasm, were specifically stained in the epidermal sheet, suggesting that LC granule are derived from invagination of LC cytommbraneand retain T6 antigen. Expand
Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin
TLDR
It is suggested that during DL, inflammatory stimuli in the skin increase the migration of LCs to the lymph node but without associated maturation, indicating that LC migration and maturation can be independently regulated events. Expand
Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells
TLDR
The DAMP-technique is used to monitor acidic organelles at the ultrastructural level in fresh, as well as cultured, mouse and human LC to support the notion that endosomes are critical for antigen processing and suggest that LC granules might be involved as well. Expand
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TLDR
It is demonstrated that LCG are an adsorptive endocytic organelle that is derived from plasma membrane invaginations that collected ferritin particles in a saclike extension at the end. Expand
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