Langerhans cells down-regulate inflammation-driven alveolar bone loss.

  title={Langerhans cells down-regulate inflammation-driven alveolar bone loss.},
  author={Moran Arizon and Itay Nudel and Hadas Segev and Gabriel Mizraji and Mazal Elnekave and Karina Furmanov and Luba Eli-Berchoer and Bj{\"o}rn E Clausen and Lior Shapira and Asaf Wilensky and Avi-Hai Hovav},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 18},
Excessive bone resorption is frequently associated with chronic infections and inflammatory diseases. Whereas T cells were demonstrated to facilitate osteoclastogenesis in such diseases, the role of dendritic cells, the most potent activators of naive T cells, remains unclear. Using a model involving inflammation-driven alveolar bone loss attributable to infection, we showed that in vivo ablation of Langerhans cells (LCs) resulted in enhanced bone loss. An increased infiltration of B and T… CONTINUE READING
18 Citations
51 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 51 references

Regulatory T cells attenuate experimental periodontitis pro- gression in mice

  • GP Garlet
  • J Clin Periodontol
  • 2010

Similar Papers

Loading similar papers…