Langerhans cells down-regulate inflammation-driven alveolar bone loss.

@article{Arizon2012LangerhansCD,
  title={Langerhans cells down-regulate inflammation-driven alveolar bone loss.},
  author={Moran Arizon and Itay Nudel and Hadas Segev and Gabriel Mizraji and Mazal Elnekave and Karina Furmanov and Luba Eli-Berchoer and Bj{\"o}rn E Clausen and Lior Shapira and Asaf Wilensky and Avi-Hai Hovav},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 18},
  pages={7043-8}
}
Excessive bone resorption is frequently associated with chronic infections and inflammatory diseases. Whereas T cells were demonstrated to facilitate osteoclastogenesis in such diseases, the role of dendritic cells, the most potent activators of naive T cells, remains unclear. Using a model involving inflammation-driven alveolar bone loss attributable to infection, we showed that in vivo ablation of Langerhans cells (LCs) resulted in enhanced bone loss. An increased infiltration of B and T… CONTINUE READING
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