Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice.

@article{Elentner2009LangerhansCA,
  title={Langerhans cells are critical in the development of atopic dermatitis-like inflammation and symptoms in mice.},
  author={Andreas Elentner and Daniela Finke and Matthias Schmuth and Stephane Chappaz and Susanne Ebner and Bernard Malissen and Adrien Kissenpfennig and Nikolaus Romani and Sandrine Dubrac},
  journal={Journal of cellular and molecular medicine},
  year={2009},
  volume={13 8B},
  pages={
          2658-72
        }
}
Genetic or vitamin D3-induced overexpression of thymic stromal lymphopoietin (TSLP) by keratinocytes results in an atopic dermatitis (AD)-like inflammatory phenotype in mice echoing the discovery of high TSLP expression in epidermis from AD patients. Although skin dendritic cells (DC) are suspected to be involved in AD, direct evidence of a pathogenetic role for skin DC in TSLP-induced skin inflammation has not yet been demonstrated. In a mouse model of AD, i.e. mice treated with the low… CONTINUE READING

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