Langerhans cell histiocytosis with intrathymic calcifications and cavitation

@article{Crawley2010LangerhansCH,
  title={Langerhans cell histiocytosis with intrathymic calcifications and cavitation},
  author={Alexis Crawley and R. Paul Guillerman},
  journal={Pediatric Radiology},
  year={2010},
  volume={40},
  pages={62}
}
A 3-month-old boy presented with respiratory distress, cough, poor feeding and a mediastinal mass on a chest radiograph. A CT scan of the chest demonstrated diffuse thymic enlargement with punctate intrathymic calcifications (Fig. 1) and cavitation (Fig. 2). A diagnosis of Langerhans cell histiocytosis (LCH) was suggested based on the CT findings and confirmed by biopsy of a skin rash. Granulomatous infiltration of the thymus by dendritic cells is common in pediatric LCH, especially in… 
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TLDR
C Cavitation within mediastinal masses in histiocytosis-X appears to reflect two processes; the first is necrosis within the masses themselves and the second is involvement of adjacent lung with adherence of lung and pleura to the mediastinum allowing air to fill the mediastsinal cavities.
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TLDR
Four new cases of punctate thymic calcification in infants with untreated Langerhans' cell histiocytosis (LCH) are added and the finding of such punctate calcific densities in an enlarged thymus of an infant with skin or bone or lung disease is strongly suggestive of LCH.