Langerhans cell histiocytosis with intrathymic calcifications and cavitation

  title={Langerhans cell histiocytosis with intrathymic calcifications and cavitation},
  author={Alexis Crawley and R. Paul Guillerman},
  journal={Pediatric Radiology},
A 3-month-old boy presented with respiratory distress, cough, poor feeding and a mediastinal mass on a chest radiograph. A CT scan of the chest demonstrated diffuse thymic enlargement with punctate intrathymic calcifications (Fig. 1) and cavitation (Fig. 2). A diagnosis of Langerhans cell histiocytosis (LCH) was suggested based on the CT findings and confirmed by biopsy of a skin rash. Granulomatous infiltration of the thymus by dendritic cells is common in pediatric LCH, especially in… 
Multisystem langerhans cell histiocytosis with thymic involvement diagnosed with anterior mediastinal mass in a 2-month-old boy.
A 2-month-old-boy admitted to hospital with a giant anterior mediastinal mass with multisystem LCH involving the thymus, lungs, liver and skin is reported.
Histologic Patterns of Thymic Involvement in Langerhans Cell Proliferations: A Clinicopathologic Study and Review of the Literature
4 distinct pathologic groups of thymic involvement in Langerhans cell proliferations with relevance for diagnosis and treatment are proposed.
Thymus and Mediastinal Node Involvement in Childhood Langerhans Cell Histiocytosis: Long-Term Follow-Up From the French National Cohort
The clinical, radiological, and biological presentation, and the outcome of childhood LCH with MI are described.
Thoracic Manifestations of Systemic Diseases
A wide variety of systemic diseases have manifestations in the pediatric chest, and knowledge of the pertinent clinical and imaging features may allow the radiologist to be the first to suggest an underlying systemic disease.
Churg–Strauss syndrome: update on pathophysiology and treatment
Current knowledge on CSS pathogenesis is evolving; the identification of key molecular mechanisms will pave the way for newer, more specific treatments.
Contemporary perspectives on pediatric diffuse lung disease.
Computed Tomography of the Pediatric Chest
CT images are helpful in detecting, characterizing and determining the extent of abnormalities in the lungs, mediastinum, vasculature, chest wall and peridiaphragmatic regions.


Cavitation of anterior mediastinal masses in children with histiocytosis-X
C Cavitation within mediastinal masses in histiocytosis-X appears to reflect two processes; the first is necrosis within the masses themselves and the second is involvement of adjacent lung with adherence of lung and pleura to the mediastinum allowing air to fill the mediastsinal cavities.
Punctate thymic calcification in infants with untreated Langerhans' cell histiocytosis: Report of four new cases
Four new cases of punctate thymic calcification in infants with untreated Langerhans' cell histiocytosis (LCH) are added and the finding of such punctate calcific densities in an enlarged thymus of an infant with skin or bone or lung disease is strongly suggestive of LCH.