Langerhans cell histiocytosis in children: History, classification, pathobiology, clinical manifestations, and prognosis.

Abstract

Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells driven by mutations in the mitogen-activated protein kinase pathway. When disease involves the skin, LCH most commonly presents as a seborrheic dermatitis or eczematous eruption on the scalp and trunk. Evaluation for involvement of other organ systems is essential… (More)
DOI: 10.1016/j.jaad.2017.05.059