Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq.

@article{Khoury2013LandscapeOD,
  title={Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq.},
  author={Joseph D Khoury and Nizar M. Tannir and Michelle Dianne Williams and Yunxin Chen and Hui Yao and Jianping Zhang and Erika J. Thompson and Funda Meric-Bernstam and L Jeffrey Medeiros and John N. Weinstein and Xiaoping Su},
  journal={Journal of virology},
  year={2013},
  volume={87 16},
  pages={
          8916-26
        }
}
Elucidation of tumor-DNA virus associations in many cancer types has enhanced our knowledge of fundamental oncogenesis mechanisms and provided a basis for cancer prevention initiatives. RNA-Seq is a novel tool to comprehensively assess such associations. We interrogated RNA-Seq data from 3,775 malignant neoplasms in The Cancer Genome Atlas database for the presence of viral sequences. Viral integration sites were also detected in expressed transcripts using a novel approach. The detection… CONTINUE READING

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