Landiolol has a less potent negative inotropic effect than esmolol in isolated rabbit hearts

@article{Ikeshita2008LandiololHA,
  title={Landiolol has a less potent negative inotropic effect than esmolol in isolated rabbit hearts},
  author={Kazutoshi Ikeshita and Kiyonobu Nishikawa and Sumiko Toriyama and Tomoyuki Yamashita and Yoshiyuki Tani and Tokuhiro Yamada and Akira Asada},
  journal={Journal of Anesthesia},
  year={2008},
  volume={22},
  pages={361-366}
}
PurposeWe compared the negative chronotropic and inotropic effects of landiolol and esmolol, two clinically available short-acting β1-blockers with high β1-selectivity, using whole isolated rabbit heart preparations.MethodsTachycardia was induced by continuous perfusion of 10−7 M isoproterenol, and we used concentrations of landiolol or esmolol in ascending steps (1 · 10−6, 3 · 10−6, 1 · 10−5, 3 · 10−5, and 1 · 10−4 M). Heart rate (HR), left ventricular developed pressure (LVDP), the maximal… 

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TLDR
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TLDR
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