Landau-Kleffner syndrome: a pharmacologic study of five cases.

@article{Marescaux1990LandauKleffnerSA,
  title={Landau-Kleffner syndrome: a pharmacologic study of five cases.},
  author={C. Marescaux and E. Hirsch and Sonja Finck and Pierre Maquet and Eric Guichemerre Schlumberger and François Sellal and Marie-No{\"e}lle Metz-Lutz and Yves Alembik and Eric Salmon and Georges Franck},
  journal={Epilepsia},
  year={1990},
  volume={31 6},
  pages={768-77}
}
Five children with Landau-Kleffner syndrome (epilepsy, acquired aphasia, and continuous spike-wave discharges during sleep), were treated with antiepileptic drugs (AEDs), sleep-modifying drugs, and corticosteroids. The pharmacologic profiles differed from those observed in focal epilepsies, resembling instead those of certain generalized epilepsies, such as West or Lennox-Gastaut syndromes. Phenobarbital (PB), carbamazepine (CBZ), and phenytoin (PHT) were ineffective or worsened the EEG and… CONTINUE READING

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